Hans-Leo Teulings on Movement Side Effects of Schizophrenia Medication

Hans-Leo Teulings

IGS Website Manager (2007-2017)
Dr. Hans-Leo Teulings received a MS in experimental physics and biophysics and a PhD in experimental psychology. During more than 30 years he contributed to many grant applications and research papers on handwriting movement analysis. Since 1997 he is CEO of NeuroScript®. www.NeuroScript.net offers MovAlyzeR® handwriting analysis software which is used worldwide for scientific research and professional application.

Handwriting analysis is a sensitive measure to automatically detect movement side effects due to overmedication in schizophrenia. Conventional measures still in use by psychiatrists and pharmaceuticals show no significant side effects. Overmedication may be causing permanent brain damage in 20% of the schizophrenia patients.

Figure 1. Conventional methods (left panels) show no significant (ns) dosage (top panels; 0-6 mg/d) or medication type (bottom panels: Aripiprazole, Risperidone, Olanzapine/Quetiapine) effects in schizophrenia patients but the MovAlyzeR handwriting analysis method does show significant (p<0.0001) effects (right panels).


Caligiuri MP, Teulings HL, Dean CE, Niculescu AB 3rd, Lohr JB. (2010).
Handwriting movement kinematics for quantifying extrapyramidal side effects in patients treated with atypical antipsychotics.
Psychiatry Res. 2010 May 15;177(1-2):77-83. doi: 10.1016/j.psychres.2009.07.005. Epub 2010 Apr 9.
FREE ARTICLE http://www.ncbi.nlm.nih.gov/pubmed/20381875

Caligiuri MP, Teulings HL, Dean CE, Niculescu AB, Lohr J. (2009).
Handwriting movement analyses for monitoring drug-induced motor side effects in schizophrenia patients treated with risperidone.
Hum Mov Sci. 2009 Oct;28(5):633-42. doi: 10.1016/j.humov.2009.07.007. Epub 2009 Aug 18.
FREE ARTICLE http://www.ncbi.nlm.nih.gov/pubmed/19692133

Teulings, H.L. (2010).
Motor Phenomenon Measurement.
US Patent Application US2010/0152622A1
FULL TEXT http://www.freepatentsonline.com/20100152622.pdf
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